Overview

Here, we describe a serological enzyme-linked immunosorbent assay for the screening and identification of human  SARS-CoV-2 seroconverters. This assay does not require the  handling of infectious virus, can be adjusted to detect different antibody types in serum and plasma and is amenable to  scaling. Serological assays are of critical importance to help  define previous exposure to SARS-CoV-2 in populations, identify highly reactive human donors for convalescent plasma  therapy and investigate correlates of protection.